Investigating the role of a specific gene in Parkinson's Disease and its effects on cell processes.
Neuronal roles of Parkinsons Disease Vps13C in regulating autophagy and calcium dynamics
This study is looking at how changes in the VPS13C gene might play a role in Parkinson's Disease by affecting how brain cells work, especially in cleaning up waste and managing calcium levels, to help us better understand what causes the disease in families with a history of it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10912550 on NIH RePORTER |
What this research studies
This research focuses on understanding how mutations in the VPS13C gene contribute to Parkinson's Disease by affecting neuronal functions, particularly in autophagy and calcium dynamics. The study employs advanced techniques, including mass-spectrometry and CRISPR methodologies, to explore the interactions between VPS13C and other proteins involved in cellular processes. By examining these interactions, the research aims to uncover the mechanisms that lead to neurodegeneration in patients with familial forms of Parkinson's Disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with familial Parkinson's Disease linked to VPS13C mutations.
Not a fit: Patients with sporadic forms of Parkinson's Disease or those without VPS13C mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating or preventing Parkinson's Disease.
How similar studies have performed: Previous research has shown promising results in understanding the roles of similar genes in neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Caraveopiso, Gabriela — Northwestern University at Chicago
- Study coordinator: Caraveopiso, Gabriela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.