Investigating the role of a specific gene in Parkinson's disease and dementia using a mouse model
Official title: Role of LRP10 in Parkinson's disease and dementia: a knockout mouse model
Funded at University of Connecticut Sch of Med/dnt · NIH-11135981 · Data updated 2026-11-12
This study is looking at how the missing LRP10 gene might play a role in Parkinson's disease and related dementias by using special mice without this gene to see how it affects their movement and thinking, which could help us find better ways to understand and treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $457,875 |
| NIH project number | 1R21AG094032-01 |
| Project ID | NIH-11135981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of Parkinson's disease, dementia, or related neurodegenerative conditions.
✕Less likely to help
Patients who do not have Parkinson's disease or related dementias may not benefit from this research.
What this research studies
This research focuses on understanding how the loss of the LRP10 gene contributes to Parkinson's disease and related dementias. By creating a knockout mouse model that lacks this gene, researchers aim to observe changes in movement and cognitive functions, as well as the development of specific brain pathologies. The study will utilize advanced techniques to analyze the effects of LRP10 deficiency on neurodegeneration, potentially revealing new insights into the mechanisms behind these diseases. This could lead to better understanding and treatment options for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Parkinson's disease and related dementias.
How similar studies have gone: While the specific approach of targeting LRP10 is novel, similar studies have shown success in understanding genetic contributions to neurodegenerative diseases.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Xiong, Yulan — University of Connecticut Sch of Med/dnt
- Study coordinator: Xiong, Yulan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.