Investigating the role of a specific gene in motor neuron degeneration related to ALS
Official title: Generation and analysis of mouse models to define the roles of the ALS-associated factor Zfp106/ZNF106 in neurodegeneration
Funded at University of California, San Francisco · NIH-11004380 · Data updated 2026-11-12
This study is looking at how a specific gene called Zfp106 might play a role in the development of ALS, and it's for anyone interested in understanding more about this disease and finding new ways to help those affected by it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $378,826 |
| NIH project number | 5R01NS126499-02 |
| Project ID | NIH-11004380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or related motor neuron diseases.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without a genetic component to their motor neuron disease may not benefit from this research.
What this research studies
This research focuses on understanding how the Zfp106 gene, which encodes an RNA binding protein, contributes to the development of amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases. By creating and analyzing mouse models with inactivated Zfp106, researchers aim to uncover the mechanisms behind motor neuron loss and the genetic factors that influence ALS susceptibility. The study will involve detailed biochemical analyses and assessments of motor neuron health in these models to identify potential protective roles of Zfp106. Insights gained from this research could lead to new therapeutic strategies for ALS patients.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for ALS, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in ALS, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Black, Brian L — University of California, San Francisco
- Study coordinator: Black, Brian L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.