Investigating the role of a specific gene in heart failure and obesity
Official title: Cardiac regulation of heart failure and obesity
Funded at Northwestern University at Chicago · NIH-11066826 · Data updated 2026-11-12
This study is looking at how a specific gene called MTCH2 affects heart health and weight by using special mice that don’t have this gene in their heart cells, which could help us understand the connection between obesity and heart problems, especially as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 1F32HL177905-01 |
| Project ID | NIH-11066826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with obesity or those at risk for heart failure.
✕Less likely to help
Patients without obesity or heart-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the MTCH2 gene influences heart function and body weight. By studying genetically modified mice that lack the MTCH2 protein in heart cells, researchers aim to uncover the relationship between this gene, heart health, and obesity. The study examines how changes in MTCH2 affect heart performance and fat mass, particularly under stress conditions like aging. The findings could provide insights into the mechanisms linking obesity and heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart failure in obese patients.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on heart disease and obesity, indicating potential for success in this area.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Stachowski, Marisa — Northwestern University at Chicago
- Study coordinator: Stachowski, Marisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.