Investigating the role of a specific gene in glaucoma
Official title: The role of LTBP2 in glaucoma
Funded at University of Wisconsin-Madison · NIH-10795971 · Data updated 2026-11-12
This study is looking at how a gene called LTBP2 affects different kinds of glaucoma, which is a condition that can cause high eye pressure, and it aims to find new ways to treat it by using a special animal model that acts like human glaucoma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21EY034373-02 |
| Project ID | NIH-10795971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with glaucoma or those at risk of developing the condition, particularly those with a family history of the disease.
✕Less likely to help
Patients with glaucoma caused by factors unrelated to LTBP2 or those with advanced glaucoma may not benefit from this research.
What this research studies
This research focuses on understanding how the LTBP2 gene contributes to different types of glaucoma, including congenital and adult-onset forms. Using a unique animal model that mimics human glaucoma, researchers aim to identify the cellular and molecular mechanisms that lead to increased eye pressure, a key factor in glaucoma progression. The study will explore potential therapeutic targets by examining the role of LTBP2 in the eye and its impact on the extracellular matrix. By uncovering these mechanisms, the research seeks to provide insights that could lead to new treatments for glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing and treating glaucoma, potentially preserving vision for many patients.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in glaucoma, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Mclellan, Gillian Jane — University of Wisconsin-Madison
- Study coordinator: Mclellan, Gillian Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.