Investigating the role of a specific gene in colon inflammation and cancer development
Official title: Role of Grail in colon inflammation and tumorigenesis
Funded at University of Tx Md Anderson Can Ctr · NIH-10950457 · Data updated 2026-11-12
This study is looking at how long-term inflammation in the gut can lead to colorectal cancer and is exploring the role of a gene called Grail that helps keep the intestines healthy; the goal is to find new ways to diagnose and treat people dealing with this type of cancer.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $163,500 |
| NIH project number | 1R03CA286624-01A1 |
| Project ID | NIH-10950457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic intestinal inflammation or a history of colorectal cancer.
✕Less likely to help
Patients without chronic intestinal inflammation or those who do not have a risk of colorectal cancer may not benefit from this research.
What this research studies
This research focuses on understanding how chronic intestinal inflammation contributes to the development of colorectal cancer (CRC). It examines the role of a gene called Grail, which is believed to help maintain intestinal health and control inflammation. By studying both animal models and human patients, the research aims to uncover the mechanisms by which Grail influences inflammation and tumor growth in the colon. The findings could lead to new diagnostic markers and treatment strategies for patients with inflammation-associated colorectal cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients at risk of colorectal cancer due to chronic inflammation.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cell cytokines in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Nurieva, Roza Insafetdinovna — University of Tx Md Anderson Can Ctr
- Study coordinator: Nurieva, Roza Insafetdinovna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.