Investigating the role of a specific gene in brain function related to Alzheimer's disease
TREM2-mediated microglial dynamic function in Alzheimer disease
This study is looking at how a gene called TREM2 affects brain immune cells and their role in Alzheimer's disease, using mice and human cells to see how different versions of this gene might influence brain aging and the disease's progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10765606 on NIH RePORTER |
What this research studies
This research focuses on understanding how the TREM2 gene affects the function of microglia, which are immune cells in the brain, particularly in the context of Alzheimer's disease. The study utilizes advanced mouse models and human stem cells to explore how variations in the TREM2 gene influence brain aging and the progression of Alzheimer's pathology. By examining these dynamic interactions, the research aims to clarify the role of TREM2 in the development of amyloid and tau-related brain changes associated with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease, particularly those with TREM2 gene variants.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those in advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets for treatment.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglial function in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Zhao, Na — Mayo Clinic Jacksonville
- Study coordinator: Zhao, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.