Investigating the role of a specific enzyme in the development of Parkinson's disease
Official title: NADPH Oxidase 2 in Parkinson's Disease Pathogenesis
Funded at University of Pittsburgh at Pittsburgh · NIH-10993683 · Data updated 2026-11-12
This study is looking at how a specific protein called NOX2 might play a role in the damage to brain cells in people with Parkinson's disease, using lab tests and animal models to see how it affects the health of these cells and the progression of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | December 5, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $466,915 |
| NIH project number | 5R01NS126203-03 |
| Project ID | NIH-10993683 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those experiencing early to moderate symptoms.
✕Less likely to help
Patients with advanced Parkinson's disease or those with other neurodegenerative disorders may not benefit from this research.
What this research studies
This research focuses on understanding how NADPH oxidase isoform 2 (NOX2) contributes to the degeneration of neurons in Parkinson's disease. By using advanced techniques to measure NOX2 activity in brain cells, the study aims to uncover the relationship between oxidative stress and the accumulation of toxic proteins associated with Parkinson's. The research will involve both laboratory studies and animal models to explore how NOX2 activation affects neuronal health and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting NOX2 to slow down or prevent the progression of Parkinson's disease.
How similar studies have gone: While the role of NOX2 in Parkinson's disease is still being explored, preliminary findings suggest that targeting oxidative stress pathways may have therapeutic potential, indicating a promising area of investigation.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Di Maio, Roberto — University of Pittsburgh at Pittsburgh
- Study coordinator: Di Maio, Roberto
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.