Investigating the role of a specific enzyme in movement disorders in rabbits
Probing Role of Tetrahydrobiopterin in Cerebral Palsy by Using Transgenic Rabbits
This study is looking at how a special enzyme might influence movement problems, like those seen in cerebral palsy, by observing rabbits with a genetic change that affects this enzyme, and the goal is to learn more about these issues to help kids who face similar challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10990527 on NIH RePORTER |
What this research studies
This research explores how a specific enzyme, tetrahydrobiopterin, affects movement disorders like cerebral palsy in transgenic rabbits. By creating rabbits with a genetic mutation that impacts this enzyme, researchers can observe the resulting movement issues, such as hypertonia and balance difficulties. The study uses advanced imaging techniques like MRI to analyze brain development and function in these animals, aiming to uncover the underlying mechanisms of these disorders. The findings could lead to better understanding and potential treatments for children with similar conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with cerebral palsy or related movement disorders.
Not a fit: Patients with movement disorders not linked to tetrahydrobiopterin deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating movement disorders in children.
How similar studies have performed: While the use of transgenic animal models is a well-established approach, the specific focus on tetrahydrobiopterin in this context is relatively novel.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Tan, Sidhartha — Wayne State University
- Study coordinator: Tan, Sidhartha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.