Investigating the role of a specific enzyme in inflammatory bowel disease
Exploring Glutamate Carboxypeptidase II (GCPII) Dysregulation in Human and Experimental IBD
This study is looking at how a specific enzyme called GCPII affects inflammatory bowel disease (IBD) to find new treatment options for people living with this challenging digestive condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10997310 on NIH RePORTER |
What this research studies
This research focuses on understanding how the enzyme glutamate carboxypeptidase II (GCPII) is involved in inflammatory bowel disease (IBD), a chronic condition affecting the digestive system. The principal investigator, Dr. Diane Peters, will utilize advanced techniques such as immunofluorescent imaging and CRISPR/Cas9 genome editing to explore the mechanisms of GCPII dysregulation in both human and animal models. By studying the effects of GCPII inhibitors, the research aims to identify potential new treatments for patients suffering from IBD, which currently has no cure and limited effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Not a fit: Patients with IBD who are already responding well to existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with inflammatory bowel disease.
How similar studies have performed: Previous studies have shown promising results with GCPII inhibitors in animal models, indicating potential for success in human applications.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Peters, Diane E — Johns Hopkins University
- Study coordinator: Peters, Diane E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.