Investigating the role of a specific DNA modification in cancer treatment
Official title: Requisition of Bio-RAD QX200 Digital Droplet PCR System
Funded at Texas A&m University-Kingsville · NIH-11036138 · Data updated 2026-11-12
This study is looking at how a special chemical change in our DNA, called 5-hydroxymethylcytosine, helps control how our genes work, especially in brain cells, and it aims to find out which proteins are involved in this process, particularly when our DNA is repairing itself.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University-Kingsville NIH-funded |
| Lab location | 1 site (Kingsville, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $61,533 |
| NIH project number | 3R16GM145578-02S1 |
| Project ID | NIH-11036138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers such as glioblastomas or lymphomas, particularly those interested in novel therapeutic approaches.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by the specific epigenetic changes being studied may not benefit from this research.
What this research studies
This research focuses on understanding the role of 5-hydroxymethylcytosine (5hmC) in DNA, which is crucial for regulating gene expression. The project aims to identify the proteins involved in the DNA demethylation pathway that leads to the formation of 5hmCs in human neurons. By using human induced-neurons derived from stem cells, researchers will explore how these modifications are affected during DNA damage repair, employing advanced CRISPR techniques. The goal is to develop high-throughput assays that can enhance biomedical research and drug discovery efforts.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by providing insights into the mechanisms of gene regulation and resistance to therapies.
How similar studies have gone: Previous research has shown promising results in understanding the role of epigenetic markers in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Texas A&m University-Kingsville
Kingsville, United States Active
Researchers
- Principal investigator: Kim, Haeyoung — Texas A&m University-Kingsville
- Study coordinator: Kim, Haeyoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.