Investigating the role of a specific brain area in epilepsy
The Role of Hippocampal area CA2 in Epilepsy
['FUNDING_R01'] · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · NIH-11093517
This study is looking at a part of the brain called CA2 to see how it affects epilepsy, especially in people whose seizures don't respond to medication, and it hopes to find new ways to help those patients feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NATHAN S. KLINE INSTITUTE FOR PSYCH RES (nih funded) |
| Locations | 1 site (ORANGEBURG, UNITED STATES) |
| Trial ID | NIH-11093517 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the hippocampal area CA2 contributes to epilepsy, particularly in cases where seizures are resistant to treatment. Using rodent models, the study examines the cellular and molecular mechanisms involved in seizure activity and explores potential new therapeutic approaches. The researchers aim to determine how changes in the CA2 area affect seizure frequency and severity, which could lead to improved treatments for patients with drug-resistant epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy that does not respond to standard medications.
Not a fit: Patients with well-controlled epilepsy or those who do not have drug-resistant forms of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from drug-resistant epilepsy.
How similar studies have performed: Previous research has shown promising results in understanding the role of other hippocampal areas in epilepsy, but the specific focus on CA2 is relatively novel.
Where this research is happening
ORANGEBURG, UNITED STATES
- NATHAN S. KLINE INSTITUTE FOR PSYCH RES — ORANGEBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHARFMAN, HELEN E — NATHAN S. KLINE INSTITUTE FOR PSYCH RES
- Study coordinator: SCHARFMAN, HELEN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.