Investigating the role of a specific antioxidant in intestinal health
Official title: Epithelial specific roles for GPx1 in the intestinal microenvironment
Funded at University of Iowa · NIH-11033886 · Data updated 2026-11-12
This study is looking at how a special enzyme called GPx1 helps protect the intestines from inflammation and damage, which could lead to new treatments for people with inflammatory bowel disease (IBD).
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | March 12, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $116,625 |
| NIH project number | 1R03DK141827-01 |
| Project ID | NIH-11033886 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease or those experiencing intestinal inflammation.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders or those without any bowel-related issues may not benefit from this research.
What this research studies
This research focuses on understanding how the antioxidant enzyme GPx1 affects the intestinal environment, particularly in conditions like inflammatory bowel disease (IBD). By using advanced mouse models and intestinal organoids, the study aims to explore how GPx1 influences cell growth and repair in the intestines. The goal is to uncover the protective mechanisms of GPx1 against intestinal inflammation and injury, which could lead to new therapeutic strategies for patients with IBD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory bowel disease by enhancing intestinal healing and reducing inflammation.
How similar studies have gone: Previous research has shown promising results in understanding the role of antioxidants in intestinal health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Short, Sarah Palmer — University of Iowa
- Study coordinator: Short, Sarah Palmer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.