Investigating the role of a sodium channel in osteoarthritis
Official title: The Role of Sodium Channel Nav1.7 in Osteoarthritis
Funded at Yale University · NIH-10928452 · Data updated 2026-11-12
This study is looking at how a specific protein called Nav1.7 affects pain in people with osteoarthritis, and it hopes to find new ways to help manage joint pain and slow down the damage to cartilage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | March 18, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2023 |
| Award (this year) | $755,211 |
| NIH project number | 7R01AR078035-03 |
| Project ID | NIH-10928452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from osteoarthritis, particularly those experiencing significant joint pain.
✕Less likely to help
Patients with osteoarthritis who do not experience pain or have other underlying conditions unrelated to Nav1.7 may not benefit from this research.
What this research studies
This research focuses on understanding how the sodium channel Nav1.7 is involved in osteoarthritis, a common joint disease. By analyzing gene expression in osteoarthritis patients, researchers have identified Nav1.7 as a key molecule associated with pain sensitivity in this condition. The study aims to explore how blocking Nav1.7 can affect chondrocytes, the cells in cartilage, potentially leading to new therapeutic targets for managing osteoarthritis. Patients may benefit from insights that could lead to innovative treatments aimed at slowing joint degeneration.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage pain and slow the progression of osteoarthritis.
How similar studies have gone: Other research has shown promise in targeting sodium channels for pain management, suggesting that this approach could be beneficial for osteoarthritis treatment.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Liu, Chuanju — Yale University
- Study coordinator: Liu, Chuanju
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.