Investigating the role of a protein in treating post-traumatic osteoarthritis
Official title: The Role of GPNMB in Post-Traumatic Osteoarthritis
Funded at Northeast Ohio Medical University · NIH-11071690 · Data updated 2026-11-12
This study is looking at a protein called GPNMB to see if it can help treat post-traumatic osteoarthritis, a painful joint condition, by reducing inflammation and protecting cartilage, with the hope of finding a new way to improve joint health for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $42,720 |
| NIH project number | 1F30AR085476-01 |
| Project ID | NIH-11071690 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with post-traumatic osteoarthritis.
✕Less likely to help
Patients with osteoarthritis not related to trauma or those under 21 years of age may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called GPNMB may help in treating post-traumatic osteoarthritis, a painful joint condition that affects many adults. The study will explore the protein's anti-inflammatory and cartilage-protective properties through laboratory experiments and animal models. By injecting this protein into affected joints, researchers aim to see if it can reduce cartilage damage and improve joint function. The ultimate goal is to find a new treatment option that could delay or prevent the progression of osteoarthritis.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that alleviates pain and improves mobility for patients suffering from osteoarthritis.
How similar studies have gone: Preliminary studies have shown promising results with similar approaches, indicating potential for success in this area.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Kronk, Trinity — Northeast Ohio Medical University
- Study coordinator: Kronk, Trinity
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.