Investigating the role of a protein in repairing DNA damage caused by UV light
The role of And-1 in nucleotide excision repair
This study is looking at how a protein called And-1 helps fix DNA damage from things like UV rays, which is important for people with skin cancer or conditions like Xeroderma Pigmentosum, to find better ways to prevent and treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11009542 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein, And-1, contributes to the process of nucleotide excision repair (NER), which is crucial for fixing DNA damage caused by UV radiation and other environmental factors. The study will explore the mechanisms by which And-1 influences the repair of DNA lesions, particularly in the context of skin cancer and conditions like Xeroderma Pigmentosum. By using various experimental approaches, including animal models, the research aims to uncover the physiological impacts of And-1 on DNA repair pathways, potentially leading to new insights into cancer prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Xeroderma Pigmentosum or those at high risk for skin cancer due to DNA repair deficiencies.
Not a fit: Patients with skin cancers unrelated to DNA repair mechanisms or those without genetic predispositions to NER deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating skin cancers associated with DNA damage.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Zhu, Wenge — George Washington University
- Study coordinator: Zhu, Wenge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.