Investigating the role of a protein in neurodegenerative diseases like Parkinson's and Dementia with Lewy Bodies
Role of Rab27b in synucleinopathies
This study is looking at a protein called Rab27b to see how it affects the spread of harmful proteins in diseases like Parkinson's and dementia, with the hope that understanding its role can lead to new treatments that might help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10795705 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein, Rab27b, influences the spread of misfolded proteins that contribute to neurodegenerative diseases such as Parkinson's Disease and Dementia with Lewy Bodies. The study examines the dual roles of Rab27b in promoting the degradation of harmful proteins while also facilitating their uptake in neurons. By analyzing how Rab27b functions in different contexts, the research aims to uncover critical molecular mechanisms that could lead to new therapeutic strategies. Patients may benefit from insights gained about the disease processes and potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's Disease or Dementia with Lewy Bodies.
Not a fit: Patients with other types of neurodegenerative disorders not related to αsyn misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of Rab proteins in neurodegeneration, indicating that this approach has potential for success.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Yacoubian, Talene Alene — University of Alabama at Birmingham
- Study coordinator: Yacoubian, Talene Alene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.