Investigating the role of a protein in male fruit fly cell division
Official title: The role of dTopors in Drosophila male meiosis
Funded at University of North Carolina Greensboro · NIH-10439122 · Data updated 2026-11-12
This study is looking at how a specific protein in fruit flies helps with the process of making sperm, which could teach us more about cell division and its importance for human health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Greensboro NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $436,500 |
| NIH project number | 1R15GM146201-01 |
| Project ID | NIH-10439122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals interested in the genetic and cellular mechanisms underlying cancer and cell division.
✕Less likely to help
Patients with conditions unrelated to genetic mutations affecting cell division may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how the dTopors protein affects cell division in male Drosophila, or fruit flies. By studying mutations in this protein, researchers aim to uncover its role in nuclear structure and chromosome behavior during meiosis, which is the process of cell division that produces sperm. The study employs a combination of genetic, cytological, and biochemical methods to explore the interactions between dTopors and other proteins involved in this process. This could provide insights into the mechanisms of cell division that may be relevant to human health.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cell division processes, potentially leading to new insights into cancer biology and treatment.
How similar studies have gone: Other research has shown success in understanding similar cellular mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of North Carolina Greensboro
Greensboro, United States Active
Researchers
- Principal investigator: Tomkiel Dean, John E — University of North Carolina Greensboro
- Study coordinator: Tomkiel Dean, John E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.