Investigating the role of a protein in lung disease related to blood vessel function.
Mitophagy in pulmonary hypertension: Novel roles of PTEN-Induced Kinase-1 in the pathobiology of pulmonary artery smooth muscle cell proliferation and mitochondrial dysfunction
This study is looking at how a protein called PINK1 affects lung blood vessel cells in veterans with pulmonary hypertension, hoping to find new ways to understand and treat this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project ID | NIH-10881631 on NIH RePORTER |
What this research studies
This research focuses on pulmonary hypertension (PH), a serious condition that affects blood flow in the lungs and is often seen in veterans. It explores how a protein called PTEN-induced putative kinase-1 (PINK1) influences the health of pulmonary artery smooth muscle cells (PASMC) and their role in the disease. By examining how PINK1 affects mitochondrial function and cell proliferation, the study aims to uncover new insights into the mechanisms behind PH. Patients may benefit from a better understanding of their condition and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans or individuals diagnosed with pulmonary hypertension.
Not a fit: Patients without pulmonary hypertension or those not affected by related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing pulmonary hypertension.
How similar studies have performed: While the specific role of PINK1 in pulmonary hypertension is being explored, similar research has shown promise in understanding mitochondrial dysfunction in other diseases.
Where this research is happening
Decatur, UNITED STATES
- Veterans Health Administration — Decatur, United States (Active)
Researchers
- Principal investigator: Hart, C Michael — Veterans Health Administration
- Study coordinator: Hart, C Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.