Investigating the role of a protein in kidney fibrosis
Role of Amphiregulin in kidney fibrosis
This study is looking at how a protein called Amphiregulin affects kidney health and contributes to kidney disease, with the hope of finding new ways to detect and prevent kidney problems for people who are dealing with chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10683349 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein called Amphiregulin contributes to kidney fibrosis and chronic kidney disease (CKD). By studying mouse models and human samples, the researchers aim to identify the mechanisms by which Amphiregulin activates certain pathways that lead to kidney damage. The goal is to develop new strategies for detecting and preventing the progression of kidney disease, potentially improving patient outcomes. The study involves both laboratory experiments and analysis of patient samples to establish a clear link between Amphiregulin levels and kidney health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic kidney disease or those who have experienced acute kidney injury.
Not a fit: Patients with kidney conditions unrelated to fibrosis or those who are not experiencing chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow the progression of chronic kidney disease and fibrosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of growth factors in kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Herrlich, Andreas — Washington University
- Study coordinator: Herrlich, Andreas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.