Investigating the role of a protein in inflammation related to ulcerative colitis
Role of Sam68 in Proinflammatory Signaling
This study is looking at how a protein called Sam68 affects inflammation in ulcerative colitis, with the goal of finding new ways to help people manage their symptoms better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11083683 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein Sam68 contributes to inflammation in ulcerative colitis, a chronic inflammatory bowel disease. By examining the signaling pathways activated by proinflammatory cytokines, the study aims to identify new therapeutic strategies that could improve treatment outcomes for patients. The researchers will use both human and animal models to explore the mechanisms by which Sam68 influences inflammation in intestinal cells. This could lead to innovative approaches to manage ulcerative colitis more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ulcerative colitis who have not responded well to current treatments.
Not a fit: Patients with other forms of inflammatory bowel disease, such as Crohn's disease, may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control inflammation in ulcerative colitis, potentially improving patient quality of life.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory pathways in ulcerative colitis, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Ramakrishnan, Parameswaran — Case Western Reserve University
- Study coordinator: Ramakrishnan, Parameswaran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.