Investigating the role of a protein in immune cell behavior and heart disease.
The Role of SECTM1 in Monocyte Biology and Atherosclerosis
This study is looking at how a protein called SECTM1 affects immune cells related to heart disease, and it aims to find new ways to treat conditions like atherosclerosis that can lead to heart problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10898054 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein, SECTM1, influences the behavior of immune cells called monocytes and its connection to atherosclerosis, a condition that leads to heart disease. The approach involves using advanced techniques in proteomics and human genetics to uncover the underlying mechanisms of this relationship. The findings will be tested in small animal models to validate the results and explore potential therapeutic targets. Patients may benefit from insights that could lead to new treatments for cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with cardiovascular disease.
Not a fit: Patients with conditions unrelated to atherosclerosis or immune cell function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart disease by targeting immune cell behavior.
How similar studies have performed: Previous research has shown promising results in understanding immune cell roles in cardiovascular diseases, suggesting this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Tahir, Usman a. — Beth Israel Deaconess Medical Center
- Study coordinator: Tahir, Usman a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.