Investigating the role of a protein in heart failure
Roles of neuropilin-1 in endothelial cell dysfunction
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10862580
This study is looking at how a protein called neuropilin-1 affects the cells that line blood vessels in people with heart failure, hoping to find new ways to help improve heart function for those with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10862580 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a protein called neuropilin-1 affects the function of endothelial cells in patients with heart failure with preserved ejection fraction (HFpEF). The study aims to uncover the molecular mechanisms behind endothelial cell dysfunction and its contribution to heart failure. By examining the interactions between neuropilin-1 and tumor necrosis factor-alpha (TNFα), the research seeks to identify potential therapeutic targets that could improve heart function in affected individuals. Patients may be involved in providing serum samples to help assess the role of neuropilin-1 in their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have been diagnosed with heart failure with preserved ejection fraction.
Not a fit: Patients with heart failure of other types or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and quality of life for patients with HFpEF.
How similar studies have performed: Previous research has shown promising results in targeting endothelial cell dysfunction in heart failure, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YING — MAYO CLINIC ROCHESTER
- Study coordinator: WANG, YING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.