Investigating the role of a protein in frontotemporal dementia and ALS
Official title: CHCHD10 Frontotemporal Dementia, Molecular Mechanisms and Therapeutic Strategies
Funded at Weill Medical Coll of Cornell Univ · NIH-10972902 · Data updated 2026-11-12
This study is looking at how a protein called CHCHD10 changes in people with frontotemporal dementia and ALS, to understand how these changes might cause problems in the brain and help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 22, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $826,742 |
| NIH project number | 1R01NS139141-01 |
| Project ID | NIH-10972902 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with frontotemporal dementia or ALS, particularly those with known mutations in the CHCHD10 gene.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to CHCHD10 mutations may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind frontotemporal dementia and amyotrophic lateral sclerosis (ALS) by studying a specific protein called CHCHD10. Researchers will explore how mutations in this protein lead to the formation of harmful aggregates that may disrupt cellular functions and contribute to neurodegeneration. Using advanced biochemical and structural techniques, the study aims to identify the structural differences in these aggregates found in both animal models and human samples. This could provide insights into the disease processes and potential therapeutic targets for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating frontotemporal dementia and ALS.
How similar studies have gone: Previous research has shown promising results in understanding protein aggregation in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Fujita, Hibiki — Weill Medical Coll of Cornell Univ
- Study coordinator: Fujita, Hibiki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.