Investigating the role of a protein in epilepsy development
Role of CACHD1 in the development of temporal lobe epilepsy and absence epilepsy
This study is looking at how a protein called CACHD1 affects certain types of epilepsy, like temporal lobe and absence epilepsy, to help find new treatment options for people who don't respond well to current medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11084465 on NIH RePORTER |
What this research studies
This research focuses on understanding how the CACHD1 protein influences the development of temporal lobe epilepsy and absence epilepsy. By studying animal models, the researchers aim to uncover the mechanisms that increase neuronal excitability and seizure susceptibility linked to T-type calcium channels. The study will explore how CACHD1 modulates these channels, potentially leading to new treatment strategies for patients who do not respond to current antiepileptic drugs. The findings could provide insights into better management of epilepsy and its associated challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with temporal lobe epilepsy or absence epilepsy, especially those who have not responded well to existing medications.
Not a fit: Patients with other types of epilepsy or those who have well-controlled seizures with current treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for epilepsy, particularly for patients who currently have limited options.
How similar studies have performed: Previous research has shown promising results in understanding the role of calcium channels in epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Patel, Manoj K — University of Virginia
- Study coordinator: Patel, Manoj K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.