Investigating the role of a protein in colorectal cancer linked to inflammatory bowel disease.
Official title: The Role of CCL11 in Inflammatory and Sporadic Colorectal Cancer.
Funded at Veterans Health Administration · NIH-10918566 · Data updated 2026-11-12
This study is looking at how a protein called CCL11 affects inflammatory bowel disease (IBD) and its link to colorectal cancer, with the hope of finding new ways to help people with these conditions, and patients may have the chance to contribute by sharing samples or taking part in related check-ups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01CX002662-01A2 |
| Project ID | NIH-10918566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with inflammatory bowel disease, particularly those at risk for colorectal cancer.
✕Less likely to help
Patients without inflammatory bowel disease or those who do not have a risk of developing colorectal cancer may not benefit from this research.
What this research studies
This research focuses on understanding how the protein CCL11 contributes to inflammatory bowel disease (IBD) and its progression to colorectal cancer (CRC). By studying both human samples and mouse models, the research aims to uncover the mechanisms by which CCL11 influences immune responses and cancer development. The goal is to identify potential new therapeutic targets that could lead to better treatments for patients suffering from IBD and CRC. Patients may be involved in providing samples or participating in related clinical assessments.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of colorectal cancer in patients with inflammatory bowel disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of immune responses in colorectal cancer, indicating that this research builds on established findings.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Coburn, Lori a — Veterans Health Administration
- Study coordinator: Coburn, Lori a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.