Investigating the role of a protein in blood vessel function related to Alzheimer's disease
Official title: Role of Sox18 in neurovascular dysfunction in Alzheimer's disease
Funded at University of California, San Diego · NIH-11029187 · Data updated 2026-11-12
This study is looking at how problems with blood vessels in the brain might affect Alzheimer's disease, specifically focusing on a protein called Sox18, to help find new ways to improve brain health for people living with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $772,581 |
| NIH project number | 1R01AG090641-01 |
| Project ID | NIH-11029187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with other forms of dementia or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how neurovascular dysfunction contributes to Alzheimer's disease. It examines the role of the Sox18 protein in the blood-brain barrier and how changes in blood vessel function may lead to the progression of Alzheimer's pathology. By analyzing blood vessels from patients with Alzheimer's and comparing them to healthy controls, the study aims to uncover molecular changes that affect blood flow and brain health. This could provide insights into potential therapeutic targets for improving brain function in Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce neurodegeneration in Alzheimer's disease.
How similar studies have gone: Previous research has shown that targeting neurovascular dysfunction can lead to improvements in Alzheimer's disease models, suggesting a promising avenue for further exploration.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Daneman, Richard — University of California, San Diego
- Study coordinator: Daneman, Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.