Investigating the role of a protein in asthma and heart function
Heme allocation and disruptions in asthma and the failing heart
This study is looking at a protein called NOX5 that affects how heart cells work, especially in people with heart issues like atrial fibrillation and asthma, to find new ways to help improve heart and lung health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10756497 on NIH RePORTER |
What this research studies
This research focuses on the heme protein NADPH oxidase 5 (NOX5), which plays a critical role in cardiovascular health and disease. It aims to understand how NOX5 affects heart cell function and its involvement in conditions like atrial fibrillation and asthma. The study will utilize induced pluripotent stem cell-derived heart cells and patient tissue to explore how changes in NOX5 influence cellular processes such as calcium signaling and metabolism. By examining these mechanisms, the research seeks to uncover potential therapeutic targets for improving heart and respiratory health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with asthma, atrial fibrillation, or other cardiovascular disorders.
Not a fit: Patients without asthma or cardiovascular issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with asthma and heart conditions, improving their overall health and quality of life.
How similar studies have performed: Other research has shown promising results in understanding the role of similar proteins in cardiovascular health, indicating that this approach may yield valuable insights.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Sweeny, Elizabeth a. — Medical College of Wisconsin
- Study coordinator: Sweeny, Elizabeth a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.