Investigating the role of a protein in Alzheimer's disease and brain function
Role of PLD3 in nucleic acid recognition and brain function
This study is looking at how a protein called PLD3 might play a role in Alzheimer's disease by using mice to see how changes in the PLD3 gene affect brain health, with the hope of finding new ways to help people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10525053 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein Phospholipase D3 (PLD3) contributes to neurodegeneration, particularly in Alzheimer's disease. Researchers will use mouse models to explore how mutations in the PLD3 gene affect brain function and disease progression. By examining the role of PLD3 in recognizing nucleic acids and its interactions with other proteins, the study aims to uncover mechanisms that could lead to new therapeutic strategies. The research will also assess the impact of PLD3 deficiency on brain inflammation and neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations related to Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with non-genetic forms of dementia or those without any familial history of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Nemazee, David — Scripps Research Institute, the
- Study coordinator: Nemazee, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.