Investigating the role of a protein in Alzheimer's disease
AQP4 Associations with Alzheimer's Disease: A Multi-omics Approach
This study is looking at a protein called aquaporin-4 and how it might affect Alzheimer's disease by helping the brain get rid of harmful plaques, and we're inviting patients to share samples or information that could help us understand this better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10825038 on NIH RePORTER |
What this research studies
This research explores how the aquaporin-4 (AQP4) protein is associated with Alzheimer's disease (AD) and its impact on the brain's ability to clear harmful amyloid plaques. By analyzing genetic and expression changes in AQP4 and its regulatory components in large human studies, the research aims to understand how these factors contribute to AD pathology. The study utilizes advanced computational methods to analyze data from well-characterized cohorts, providing insights into the mechanisms of AD progression. Patients may be involved in providing biological samples or data that can help elucidate these relationships.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance amyloid clearance and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of the glymphatic system in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Phillips, Jared — Vanderbilt University
- Study coordinator: Phillips, Jared
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.