Investigating the role of a protein in allergic asthma
Nuclear Receptor REV-ERB alpha Role in the Pathophysiology of Allergic Asthma
This study is looking at how a protein called REV-ERBα affects allergic asthma and how it might help us find better ways to treat asthma symptoms and inflammation caused by allergens like dust mites.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10643859 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein REV-ERBα affects allergic asthma, particularly its role in the body's daily rhythms and immune responses. Researchers will study how changes in REV-ERBα levels in the lungs can influence asthma symptoms and inflammation, especially in response to common allergens like house dust mites. By examining these mechanisms, the study aims to identify new ways to improve asthma treatment and management for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with allergic asthma, particularly those experiencing severe symptoms or poor response to current treatments.
Not a fit: Patients with non-allergic asthma or those whose asthma is well-controlled with existing therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better control asthma symptoms and reduce inflammation.
How similar studies have performed: Previous studies have indicated that targeting circadian rhythms and related proteins may offer new insights into asthma management, suggesting potential for success in this novel approach.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Sundar, Isaac Kirubakaran — University of Kansas Medical Center
- Study coordinator: Sundar, Isaac Kirubakaran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.