Investigating the role of a protein in advanced prostate cancer
The Role of YY1 in Castration-Resistant Prostate Cancer
This study is looking at how a protein called YY1 affects castration-resistant prostate cancer, which is a tough type of prostate cancer that doesn't respond to regular treatments, to help find new ways to fight it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10914916 on NIH RePORTER |
What this research studies
This research focuses on understanding how the YY1 protein contributes to castration-resistant prostate cancer (CRPC), a severe form of prostate cancer that does not respond to standard treatments. The study examines the mechanisms by which YY1 influences cancer cell metabolism and growth, particularly through its interaction with the androgen receptor variant AR-V7. By analyzing tumor samples and using advanced genomic techniques, the researchers aim to uncover how YY1 promotes cancer progression and resistance to therapies. The findings could lead to new therapeutic strategies targeting YY1 and its pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with castration-resistant prostate cancer who have not responded to standard therapies.
Not a fit: Patients with early-stage prostate cancer or those who have not developed resistance to standard treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with castration-resistant prostate cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Cai, Ling — Duke University
- Study coordinator: Cai, Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.