Investigating the role of a protein in a childhood vascular disease
Official title: Role of HMGB1 in an experimental model of Bacterial ligand induced Vasculitis
Funded at Cedars-Sinai Medical Center · NIH-11216258 · Data updated 2026-11-12
This study is looking at Kawasaki Disease in kids to see how a protein called HMGB1 affects the illness and heart issues, with hopes of finding new treatments for children who don’t get better with usual care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 20, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $420,656 |
| NIH project number | 1R21AI193709-01 |
| Project ID | NIH-11216258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old diagnosed with Kawasaki Disease.
✕Less likely to help
Patients with Kawasaki Disease who respond well to standard treatments like intravenous immunoglobulin may not benefit from this research.
What this research studies
This research focuses on Kawasaki Disease, a serious condition affecting children that can lead to heart problems. The study aims to understand how a protein called HMGB1 contributes to the disease's progression and the development of coronary artery aneurysms. By using a specific bacterial model, researchers will explore the inflammatory processes involved in Kawasaki Disease and test potential new treatments that could improve outcomes for affected children. The goal is to identify better therapeutic strategies for those who do not respond to standard treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Kawasaki Disease, reducing the risk of heart complications in children.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammatory mediators in Kawasaki Disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Arditi, Moshe — Cedars-Sinai Medical Center
- Study coordinator: Arditi, Moshe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.