Investigating the role of a protein in a childhood vascular disease
Role of HMGB1 in an experimental model of Bacterial ligand induced Vasculitis
This study is looking at Kawasaki Disease in kids to see how a protein called HMGB1 affects the illness and heart issues, with hopes of finding new treatments for children who don’t get better with usual care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11216258 on NIH RePORTER |
What this research studies
This research focuses on Kawasaki Disease, a serious condition affecting children that can lead to heart problems. The study aims to understand how a protein called HMGB1 contributes to the disease's progression and the development of coronary artery aneurysms. By using a specific bacterial model, researchers will explore the inflammatory processes involved in Kawasaki Disease and test potential new treatments that could improve outcomes for affected children. The goal is to identify better therapeutic strategies for those who do not respond to standard treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with Kawasaki Disease.
Not a fit: Patients with Kawasaki Disease who respond well to standard treatments like intravenous immunoglobulin may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Kawasaki Disease, reducing the risk of heart complications in children.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory mediators in Kawasaki Disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Arditi, Moshe — Cedars-Sinai Medical Center
- Study coordinator: Arditi, Moshe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.