Investigating the role of a protein complex in DNA replication and cell division.
Official title: DNA Replication and Cytokinesis.
Funded at University of Alabama at Birmingham · NIH-10930798 · Data updated 2026-11-12
This study is looking at a tiny part of a protein called Orc6 to see how it helps cells copy their DNA and divide properly, using fruit flies to learn more about how changes in Orc6 might be linked to developmental issues like Meier-Gorlin syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $371,250 |
| NIH project number | 5R35GM148158-02 |
| Project ID | NIH-10930798 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Meier-Gorlin syndrome or related genetic disorders that affect growth and development.
✕Less likely to help
Patients without genetic disorders related to DNA replication or cytokinesis may not benefit from this research.
What this research studies
This research focuses on understanding how the Origin Recognition Complex (ORC), particularly its smallest subunit Orc6, is involved in both DNA replication and the process of cytokinesis, which is the division of a cell's cytoplasm. Using Drosophila as a model organism, the researchers will explore how mutations in Orc6 can lead to developmental disorders like Meier-Gorlin syndrome. The study aims to dissect the molecular functions of Orc6 to provide insights into its roles in cell division and replication, which could have implications for understanding certain genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for genetic disorders associated with DNA replication and cell division abnormalities.
How similar studies have gone: Previous research has shown success in using model organisms like Drosophila to study genetic disorders, indicating that this approach is promising.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Chesnokov, Igor N — University of Alabama at Birmingham
- Study coordinator: Chesnokov, Igor N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.