Investigating the role of a protein complex in cancers with Myc gene amplification
Phase Separation-involved Roles of Mediator Complex in Myc-amplified Cancer
This study is looking at how a specific protein called MED30 helps certain aggressive cancers grow, especially those with a lot of Myc gene activity, to find new ways to treat these cancers and improve outcomes for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10764837 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Mediator complex, particularly the MED30 protein, contributes to the progression of cancers that have high levels of Myc gene amplification. By examining the interactions and functions of MED30 within the Mediator complex, the study aims to identify potential therapeutic targets for these aggressive cancers. The approach includes analyzing the structural and functional roles of MED components and their impact on gene expression regulation in cancer cells. Patients may benefit from insights that could lead to new treatment strategies targeting Myc-amplified tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that exhibit Myc gene amplification.
Not a fit: Patients with cancers not associated with Myc amplification may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with Myc-amplified cancers.
How similar studies have performed: Previous research has shown promising results in targeting components of the Mediator complex in cancer, suggesting that this approach may be effective.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Jin, Chunyu — University of California, San Diego
- Study coordinator: Jin, Chunyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.