Investigating the role of a protein called BRD4 in blood cell formation and cancer.
Role of BRD4 in Normal Hematopoiesis and Hematopoietic Stem Cell Biology
This study is looking at how a protein called BRD4 affects the growth and function of blood cells, especially in stem cells, to better understand its role in healthy blood production and leukemia, which could help develop new treatments for blood cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10744741 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein BRD4 influences the formation and function of blood cells, particularly in the context of hematopoietic stem cells. By using a specialized mouse model, researchers will explore how changes in BRD4 levels affect blood cell development and the potential transformation into leukemia. The study aims to fill a critical knowledge gap regarding BRD4's role in both normal blood cell production and its implications in blood cancers, which could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hematological malignancies or those interested in the biology of blood cell formation.
Not a fit: Patients with solid tumors unrelated to hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies targeting BRD4 for patients with blood cancers, improving treatment outcomes.
How similar studies have performed: Previous research has shown that targeting BRD4 can be effective in treating certain cancers, indicating a promising avenue for further exploration.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Yang, Feng-Chun — University of Texas Hlth Science Center
- Study coordinator: Yang, Feng-Chun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.