Investigating the role of a mutant protein in muscle and its link to Alzheimer's disease
Skeletal Muscular Swedish Mutant APP in Alzheimer's Disease Development
This study is looking at how a certain change in a protein found in muscles might be linked to Alzheimer's disease, and it aims to help us understand how muscle health could affect brain problems in people with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louis Stokes Cleveland VA Medical Center NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10948895 on NIH RePORTER |
What this research studies
This research explores how a specific mutant form of the amyloid precursor protein (APPswe) found in skeletal muscles may contribute to the development of Alzheimer's disease (AD). The study aims to understand the mechanisms by which changes in APP metabolism in muscles could influence brain pathology associated with AD. Researchers will utilize animal models to observe muscle weakness and other physical changes that occur before any detectable brain damage, providing insights into the relationship between muscle health and cognitive decline in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients who do not have Alzheimer's disease or related risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and intervention in Alzheimer's disease by highlighting the importance of muscle health.
How similar studies have performed: While the focus on muscle contributions to Alzheimer's is relatively novel, there have been successful studies linking physical health to cognitive decline in other contexts.
Where this research is happening
Cleveland, United States
- Louis Stokes Cleveland VA Medical Center — Cleveland, United States (Active)
Researchers
- Principal investigator: Xiong, Wen-Cheng — Louis Stokes Cleveland VA Medical Center
- Study coordinator: Xiong, Wen-Cheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.