Investigating the role of a liver-derived factor in improving brain function in older adults
Pro-youthful role of Gpld1 on regenerative and cognitive function in the aged brain
This study is looking at a protein called Gpld1 in the blood to see if it can help boost brain function and healing in older adults, especially those with Alzheimer's, by building on what we know about how exercise benefits brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11086641 on NIH RePORTER |
What this research studies
This research explores how a specific protein, Gpld1, found in the blood, may help improve cognitive function and regenerative abilities in the aging brain. The study builds on previous findings that exercise can enhance brain health and memory in older adults, particularly those with Alzheimer's disease. By examining the effects of Gpld1, the researchers aim to understand its potential to reverse age-related cognitive decline and improve neurogenesis. Patients may be involved in trials assessing the impact of this protein on cognitive performance and overall brain health.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults experiencing cognitive decline or those at risk for age-related cognitive disorders.
Not a fit: Patients who are not experiencing cognitive decline or who are younger than 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive function and delay the onset of dementia in older adults.
How similar studies have performed: Previous research has shown promising results in using exercise and related factors to improve cognitive function in aging populations, suggesting a potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Villeda, Saul a — University of California, San Francisco
- Study coordinator: Villeda, Saul a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.