Investigating the role of a hormone in bone and kidney health in sickle cell disease.
Role of FGF23 in Bone, Kidney, Blood, Crosstalk in Sickle Cell Disease Mice
This study is looking at how a protein called FGF23 impacts bone health and kidney function in people with sickle cell disease, aiming to find new ways to help improve bone strength for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11017025 on NIH RePORTER |
What this research studies
This research focuses on understanding how fibroblast growth factor 23 (FGF23) affects bone health and kidney function in individuals with sickle cell disease (SCD). The study examines the mechanisms behind low bone mineral density in SCD patients, which is often not linked to typical risk factors. By using a mouse model of SCD, researchers will explore how anemia and related factors influence FGF23 levels and bone mineralization. The goal is to identify potential therapeutic targets to improve bone health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with sickle cell disease who are experiencing low bone mineral density.
Not a fit: Patients without sickle cell disease or those with other underlying conditions affecting bone health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone health and reduce osteoporosis in patients with sickle cell disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of FGF23 in anemia, suggesting that this approach may yield valuable insights.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Hurley, Marja Marie — University of Connecticut Sch of Med/dnt
- Study coordinator: Hurley, Marja Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.