Investigating the role of a gene in intestinal immune balance
Role of SCGN in Intestinal Immune Homeostasis
This study is looking at how changes in a specific gene might affect gut health and contribute to inflammatory bowel disease, like ulcerative colitis, to help find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10791764 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic variations, particularly in the SCGN gene, contribute to inflammatory bowel disease (IBD), such as ulcerative colitis. The approach involves studying the effects of these genetic mutations on hormone secretion and immune responses in the gut. By using animal models, researchers aim to uncover the mechanisms by which SCGN influences intestinal health and disease susceptibility. The ultimate goal is to identify new therapeutic targets for treating IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to inflammatory bowel disease, particularly those with early-onset ulcerative colitis.
Not a fit: Patients with inflammatory bowel disease who do not have genetic factors related to SCGN may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in inflammatory bowel disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Sifuentes-Dominguez, Luis — Ut Southwestern Medical Center
- Study coordinator: Sifuentes-Dominguez, Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.