Investigating the role of a gene in high blood pressure and kidney damage in Black individuals
Role of LSD1 in Hypertension and Renal Injury in Blacks
This study is looking at how changes in a specific gene might influence blood pressure and kidney health in Black individuals, and it will also test different blood pressure medications to find the best options for people based on their genetics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897875 on NIH RePORTER |
What this research studies
This research focuses on understanding how variations in the LSD1 gene affect blood pressure regulation and kidney health specifically in Black individuals. The study will analyze data from a large cohort to determine if those with certain genetic markers show more signs of kidney damage. Additionally, it will involve a clinical trial where participants will receive different types of blood pressure medications to see which is more effective based on their genetic profile. This approach aims to personalize treatment for better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are Black individuals with hypertension, particularly those who may carry specific genetic variations related to the LSD1 gene.
Not a fit: Patients who do not have hypertension or those who are not of Black descent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for high blood pressure and kidney injury in Black patients.
How similar studies have performed: Other research has shown promising results in using genetic information to tailor treatments for hypertension, indicating that this approach could be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Haas, Andrea — Brigham and Women's Hospital
- Study coordinator: Haas, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.