Investigating the role of a gene in heart rhythm disorders.
The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation
This study is looking at how a gene called ERBB4 affects the heart's electrical activity, especially for people with atrial fibrillation, a common heart rhythm issue, by using mice to see how changes in this gene might lead to heart problems as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893449 on NIH RePORTER |
What this research studies
This research focuses on understanding how the ERBB4 gene influences the electrical activity of the heart, particularly in relation to atrial fibrillation (AF), a common heart rhythm disorder. By using mouse models with altered ERBB4 expression, the researchers aim to uncover how changes in this gene contribute to the development of AF, especially in the context of aging and heart disease. The study involves analyzing the electrical properties of the heart's atria to determine the impact of ERBB4 on heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of atrial fibrillation or those at risk due to factors like aging or heart disease.
Not a fit: Patients without atrial fibrillation or related heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for atrial fibrillation, potentially reducing the risk of stroke and improving heart health.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors contributing to atrial fibrillation, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Park, David S — New York University School of Medicine
- Study coordinator: Park, David S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.