Investigating the role of a gene in certain types of childhood leukemia
Official title: Role of BCL11B in lineage ambiguous leukemia
Funded at St. Jude Children's Research Hospital · NIH-10932295 · Data updated 2026-11-12
This study is looking at a tough type of leukemia that affects kids, trying to learn more about a specific gene called BCL11B to find better ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $136,176 |
| NIH project number | 5K99CA279756-02 |
| Project ID | NIH-10932295 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with acute leukemias of ambiguous lineage.
✕Less likely to help
Patients with other types of leukemia or those outside the specified age range may not benefit from this research.
What this research studies
This research focuses on acute leukemias of ambiguous lineage, which are high-risk leukemia subtypes affecting children. The study aims to understand the genetic and molecular factors that complicate treatment choices for these leukemias. By examining a specific gene, BCL11B, and its role in the development of these leukemias, researchers hope to identify more effective and tailored therapeutic strategies. The approach includes using advanced techniques like CRISPR to model the disease and explore how certain blood stem cells respond to this gene's activation.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for children with high-risk leukemia, improving their chances of recovery.
How similar studies have gone: Other research has shown promise in using genetic approaches to understand and treat leukemia, suggesting that this study could build on existing knowledge.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Montefiori, Lindsey — St. Jude Children's Research Hospital
- Study coordinator: Montefiori, Lindsey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.