Investigating the role of a gene in certain types of childhood leukemia
Role of BCL11B in lineage ambiguous leukemia
This study is looking at a tough type of leukemia that affects kids, trying to learn more about a specific gene called BCL11B to find better ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10932295 on NIH RePORTER |
What this research studies
This research focuses on acute leukemias of ambiguous lineage, which are high-risk leukemia subtypes affecting children. The study aims to understand the genetic and molecular factors that complicate treatment choices for these leukemias. By examining a specific gene, BCL11B, and its role in the development of these leukemias, researchers hope to identify more effective and tailored therapeutic strategies. The approach includes using advanced techniques like CRISPR to model the disease and explore how certain blood stem cells respond to this gene's activation.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with acute leukemias of ambiguous lineage.
Not a fit: Patients with other types of leukemia or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for children with high-risk leukemia, improving their chances of recovery.
How similar studies have performed: Other research has shown promise in using genetic approaches to understand and treat leukemia, suggesting that this study could build on existing knowledge.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Montefiori, Lindsey — St. Jude Children's Research Hospital
- Study coordinator: Montefiori, Lindsey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.