Investigating the role of a gene in breast cancer disparities among African American women
Role of YB1 in health disparities in triple negative breast cancer
This study is looking at how a gene called YB1 affects the aggressive behavior of triple negative breast cancer in African American women, with the goal of finding better treatment options for those facing this challenging condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11058371 on NIH RePORTER |
What this research studies
This research focuses on understanding how the YB1 gene contributes to the aggressive nature of triple negative breast cancer (TNBC), particularly in African American women. The study aims to explore the biological mechanisms behind the higher incidence and poorer outcomes of TNBC in this population compared to others. By examining tumor samples and analyzing YB1 expression levels, the researchers hope to uncover insights that could lead to improved treatment strategies. The approach includes assessing the gene's role in cancer metastasis and resistance to chemotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women diagnosed with triple negative breast cancer.
Not a fit: Patients with non-triple negative breast cancer or those outside the African American demographic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for African American women with triple negative breast cancer.
How similar studies have performed: Previous research has indicated that understanding genetic factors in cancer can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Sossey-Alaoui, Khalid — Case Western Reserve University
- Study coordinator: Sossey-Alaoui, Khalid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.