Investigating the role of a gene in Alzheimer's disease
The role of ABI3 in Alzheimers disease
This study is looking at how a gene called ABI3 might play a role in Alzheimer's disease by using mice to see what happens when this gene is missing, and it aims to find new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10883930 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific gene, ABI3, influences the development of Alzheimer's disease. By using mouse models, the researchers will explore how the deletion of this gene affects Alzheimer's pathology and identify key regulators involved in this process. They will also examine the impact of a rare variant of the ABI3 gene on brain function and pathology through advanced imaging and electrophysiological techniques. The goal is to uncover the mechanisms by which ABI3 contributes to Alzheimer's disease, potentially leading to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for late-onset Alzheimer's disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients with early-onset Alzheimer's disease or those without any genetic risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Other research has shown promising results in understanding genetic factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kim, Jungsu — Indiana University Indianapolis
- Study coordinator: Kim, Jungsu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.