Investigating the role of a chloride channel regulator in rare diseases
Development of tools and knowledge to facilitate the investigation of chloride channel regulator CLCA2 in rare human diseasses
This study is looking at a protein called CLCA2 that plays a role in conditions like cystic fibrosis, and researchers want to learn more about how it works in our cells to help find better treatments for related health issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10728179 on NIH RePORTER |
What this research studies
This research focuses on understanding the biological functions of the chloride channel regulator CLCA2, which is linked to inflammatory diseases such as cystic fibrosis. The project aims to develop new tools and knowledge to explore how CLCA2 regulates calcium-activated chloride channels in human cells. By creating specific monoclonal antibodies for CLCA2, researchers will analyze samples from healthy and diseased tissues to gain insights into its role in health and disease. This could lead to better understanding and potential treatments for conditions associated with CLCA2.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cystic fibrosis or other related inflammatory diseases.
Not a fit: Patients with conditions unrelated to chloride channel regulation or those not diagnosed with the target diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for rare diseases like cystic fibrosis and other inflammatory conditions.
How similar studies have performed: Previous research on related chloride channel regulators has shown promising results, indicating potential for success in this area as well.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Brett, Thomas John — Washington University
- Study coordinator: Brett, Thomas John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.