Investigating the RNA content of brain-derived exosomes
Delineating the RNA cargo of exosomes from brain microenvironment
This study is looking at tiny particles released from brain cells in people with Alzheimer's disease to see how they help brain cells communicate and if they can be used to find signs of the disease or how well treatments are working.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10511414 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular components of extracellular vesicles (EVs) released from brain cells, particularly in the context of Alzheimer's disease. By analyzing these vesicles, which carry important biological information, the study aims to uncover how they contribute to communication between brain cells and their potential role in disease progression. The research will involve isolating and characterizing these vesicles from various biofluids, such as blood and cerebrospinal fluid, to identify biomarkers that could indicate disease status or treatment response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for early detection and monitoring of Alzheimer's disease, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles as biomarkers in various diseases, suggesting a potential for success in this novel approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dogra, Navneet — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dogra, Navneet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.