Investigating the risk factors and incidence of dementia in ICU survivors
BRAIN-ICU-2 Study: Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction (Dementia) in ICU Survivors, 2nd Study
This study is looking at patients in the ICU who experience confusion, called delirium, after serious breathing problems or shock, to see how it might affect their thinking and memory later on, similar to Alzheimer's, and to find ways to help prevent these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10768538 on NIH RePORTER |
What this research studies
This research focuses on patients who have been admitted to the Intensive Care Unit (ICU) due to respiratory failure or shock, where a significant number develop delirium. The study aims to understand how this delirium can lead to long-term cognitive impairments similar to Alzheimer's disease. By examining the relationship between ICU-related delirium and subsequent dementia, the researchers hope to identify potential interventions to prevent or mitigate these cognitive issues. The study utilizes neuroimaging techniques to explore brain changes associated with delirium.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been admitted to the ICU with respiratory failure or shock and have experienced delirium during their stay.
Not a fit: Patients who have preexisting dementia or cognitive impairments prior to their ICU admission may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to strategies that prevent or reduce the risk of dementia in ICU survivors.
How similar studies have performed: Previous studies, including the BRAIN-ICU-1 study, have shown significant findings regarding cognitive impairments in ICU survivors, indicating that this research builds on established knowledge in the field.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Ely, E Wesley — Vanderbilt University Medical Center
- Study coordinator: Ely, E Wesley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.