Investigating the relationship between the immune system and metabolism in type 1 diabetes
Official title: Models to study the synergy between autoimmunity and metabolism in T1D
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11059508 · Data updated 2026-11-12
This study is looking at how the immune system affects insulin-producing cells in people with type 1 diabetes, using special mouse models to help find better treatments for managing or preventing the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,208,620 |
| NIH project number | 1UG3DK142192-01 |
| Project ID | NIH-11059508 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are interested in understanding their condition better and potentially contributing to new treatment developments.
✕Less likely to help
Patients with type 2 diabetes or those without autoimmune diabetes may not benefit from this research.
What this research studies
This research explores how the immune system interacts with pancreatic cells in individuals with type 1 diabetes (T1D). By using advanced humanized mouse models and metabolic profiling, the study aims to understand the complex dynamics between immune cells and insulin-producing cells derived from stem cells. This approach allows researchers to observe how these interactions may influence the progression of T1D and to evaluate potential new treatments. Patients may benefit from insights gained that could lead to improved therapies for managing or preventing T1D.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing type 1 diabetes more effectively.
How similar studies have gone: Other research has shown promise in using humanized mouse models to study autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Brehm, Michael Allen — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Brehm, Michael Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.