Investigating the relationship between the immune system and metabolism in type 1 diabetes
Models to study the synergy between autoimmunity and metabolism in T1D
This study is looking at how the immune system affects insulin-producing cells in people with type 1 diabetes, using special mouse models to help find better treatments for managing or preventing the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11059508 on NIH RePORTER |
What this research studies
This research explores how the immune system interacts with pancreatic cells in individuals with type 1 diabetes (T1D). By using advanced humanized mouse models and metabolic profiling, the study aims to understand the complex dynamics between immune cells and insulin-producing cells derived from stem cells. This approach allows researchers to observe how these interactions may influence the progression of T1D and to evaluate potential new treatments. Patients may benefit from insights gained that could lead to improved therapies for managing or preventing T1D.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are interested in understanding their condition better and potentially contributing to new treatment developments.
Not a fit: Patients with type 2 diabetes or those without autoimmune diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing type 1 diabetes more effectively.
How similar studies have performed: Other research has shown promise in using humanized mouse models to study autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Brehm, Michael Allen — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Brehm, Michael Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.