Investigating the relationship between smell deficits and schizophrenia symptoms
Official title: Core B
Funded at Johns Hopkins University · NIH-11072040 · Data updated 2026-11-12
This study is looking at how problems with smell might be linked to certain symptoms of schizophrenia, like feeling less pleasure or having trouble thinking, and it's for people with schizophrenia who want to help us understand these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $498,059 |
| NIH project number | 5P50MH136297-02 |
| Project ID | NIH-11072040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals diagnosed with schizophrenia, particularly those experiencing negative symptoms.
✕Less likely to help
Patients with schizophrenia who do not exhibit any olfactory deficits or negative symptoms may not benefit from this research.
What this research studies
This research focuses on understanding how smell deficits relate to specific symptoms of schizophrenia, particularly negative symptoms like anhedonia and cognitive deficits. The project utilizes both human participants and animal models to explore the neurobiological processes involved, leveraging advanced imaging techniques to study the olfactory-prefrontal circuits. By employing the Research Domain Criteria framework, the research aims to provide insights into the mechanisms underlying these symptoms and improve clinical assessments. Participants may undergo clinical evaluations and imaging studies to assess their olfactory function and its connection to their schizophrenia symptoms.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for individuals with schizophrenia.
How similar studies have gone: Previous research has shown promising results in understanding the link between olfactory deficits and schizophrenia symptoms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Miller, Michael I — Johns Hopkins University
- Study coordinator: Miller, Michael I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.