Investigating the relationship between smell deficits and schizophrenia symptoms
Core B
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11072040
This study is looking at how problems with smell might be linked to certain symptoms of schizophrenia, like feeling less pleasure or having trouble thinking, and it's for people with schizophrenia who want to help us understand these connections better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11072040 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how smell deficits relate to specific symptoms of schizophrenia, particularly negative symptoms like anhedonia and cognitive deficits. The project utilizes both human participants and animal models to explore the neurobiological processes involved, leveraging advanced imaging techniques to study the olfactory-prefrontal circuits. By employing the Research Domain Criteria framework, the research aims to provide insights into the mechanisms underlying these symptoms and improve clinical assessments. Participants may undergo clinical evaluations and imaging studies to assess their olfactory function and its connection to their schizophrenia symptoms.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with schizophrenia, particularly those experiencing negative symptoms.
Not a fit: Patients with schizophrenia who do not exhibit any olfactory deficits or negative symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for individuals with schizophrenia.
How similar studies have performed: Previous research has shown promising results in understanding the link between olfactory deficits and schizophrenia symptoms, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, MICHAEL I — JOHNS HOPKINS UNIVERSITY
- Study coordinator: MILLER, MICHAEL I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.